Panel Has Produced 4 Options in 10 Years
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Each year, American doctors inject more than 3 million doses of Botox to temporarily smooth their patients' wrinkles and frown lines. But before each batch is shipped, the manufacturer puts it through one of the oldest and most controversial animal tests available.
To check the potency of its product under federal safety rules, Allergan Inc. injects mice with Botox until it finds a dose at which half of the animals die -- a rough gauge of potential harm to humans.
Animal protection groups consider "lethal dose 50," as the test is known, to be "the poster child for everything that's wrong with animal testing," said Martin Stephens, vice president for animal research issues at the Humane Society of the United States. "It's as bad as it gets, poisoning animals to death."
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